Club El Witite
There is something about a peruvian disco that makes south american travel worthwhile. get completely bombed at this club. don't stay out too late, though. taxis get hard to find after midnight, and trying to explain to them where you are staying is pretty tricky after about ten beers, especially if you can't remember the name of your hotel. if this happens, just go back in the club. they stay open until about 5:00 in the morning, anyway.
Carambola
Another decent club on the street leading up the capitania port.
Ruztikaâs
The place to try an impressive amount of cocktails with local flavours, and has a beautiful night view of the confluence of the madre de dios and tambopata rivers.